2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. AMPK activator 2

AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549).

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AMPK activator 2 Chemical Structure

AMPK activator 2 Chemical Structure

CAS No. : 2410961-69-0

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Description

AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549)[1].

IC50 & Target[1]

AMPK

 

Molecular Weight

301.31

Formula

C13H18F3N5
CAS No.
SMILES

N=C(NC(NC1=CC=C(C(F)(F)F)C=C1)=N)NCC(C)C
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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AMPK activator 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMPK activator 22410961-69-0AMPK activator2AMPK activator-2AMPKAMP-activated protein kinasefluorine-containing proguanilmTOR4EBP1p70S6KproliferationmigrationUMUC3T24A549Inhibitorinhibitorinhibit

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