2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 206

Antibacterial agent 206 (Compound 10e) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum with MIC of 0.25-1 μg/mL. Antibacterial agent 206 reduces the exopolysaccharide, eliminates the biofilm, and thus attenuates the drug resistance. Antibacterial agent 206 exhibits antibacterial activity through destory of membrane integrity, accumulation of reactive oxygen species ROS, and inhibition of DNA replication.

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Antibacterial agent 206 Chemical Structure

Antibacterial agent 206 Chemical Structure

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Antibacterial agent 206 Related Antibodies

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Description

Antibacterial agent 206 (Compound 10e) is a indolylacryloyl-derived oxacins, which exhibits broad antibacterial spectrum with MIC of 0.25-1 μg/mL. Antibacterial agent 206 reduces the exopolysaccharide, eliminates the biofilm, and thus attenuates the drug resistance. Antibacterial agent 206 exhibits antibacterial activity through destory of membrane integrity, accumulation of reactive oxygen species ROS, and inhibition of DNA replication[1].

In Vitro

Antibacterial agent 206 exhibits antimicrobial activity against Enterococcus, Staphylococcus, Escherichia, Acinetobacter and Pseudomonas strains with MIC between 0.25-1 μg/mL[1].
Antibacterial agent 206 (0-256 μg/mL) exhibits low hemolysis, low cytotoxicity in blood, human hepatocytes (LO2) and HUVECs, and good compatibility with red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 206 Related Antibodies

Cell Viability Assay[1]

Cell Line: LO2, HUVEC
Concentration: 2-64 μg/mL
Incubation Time:
Result: Inhibited cell viability slightly in dose-dependent manner.
Molecular Weight

557.57

Formula

C30H28FN5O5
SMILES

O=C(N1CCN(C2=C(F)C=C3C(N(CC)C=C(C(O)=O)C3=O)=C2)CC1)/C(C#N)=C/C4=CN(CCO)C5=C4C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 206 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 206Antibacterial agent206Antibacterial agent-206BacterialLO2HUVECEnterococcusStaphylococcusEscherichiaPseudomonasInhibitorinhibitorinhibit

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Antibacterial agent 206
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HY-162430
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