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  3. ATF6 Antibody (YA604)

ATF6 Antibody (YA604)

Cat. No.: HY-P80554
COA User Guide for Antibodies

ATF6 Antibody (YA604) is a non-conjugated and Rabbit origined monoclonal antibody about 75 kDa, targeting to ATF6. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL $70 In-stock
50 μL $185 In-stock
100 μL $300 In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

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Description

ATF6 Antibody (YA604) is a non-conjugated and Rabbit origined monoclonal antibody about 75 kDa, targeting to ATF6. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

Background

ATF6: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

Tag

Free

Gene ID

22926

Synonyms
activating transcription factor 6; ATF6A
Molecular Weight

Predicted band size: 75 kDa

Purity

affinity purified

Conjugation

Non-conjugated

Research Field

Epigenetics and Nuclear Signaling

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Host

Rabbit

Reactivity

Human

SwissProt ID

P18850

Dilution Ratio

WB: 1:500-1:1,000 ;IHC: 1:50-1:100 ;IP: 1:20

Application

WB, IHC-P, IP

Appearance

Liquid

Formulation

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Immunogen

Synthetic peptide corresponding to Human ATF6.The exact sequence is proprietary to MCE.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ATF6 Antibody (YA604)
Cat. No.:
HY-P80554
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