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  4. Noggin Antibody (YA698)

Noggin Antibody (YA698)

Cat. No.: HY-P80767
COA User Guide for Antibodies

Noggin Antibody (YA698) is a non-conjugated and Mouse origined monoclonal antibody about 26 kDa, targeting to Noggin (1D2). It can be used for WB,ICC/IF assays with tag free, in the background of Transfected.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL $70 In-stock
50 μL $185 In-stock
100 μL $300 In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

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  • Documentation

Description

Noggin Antibody (YA698) is a non-conjugated and Mouse origined monoclonal antibody about 26 kDa, targeting to Noggin (1D2). It can be used for WB,ICC/IF assays with tag free, in the background of Transfected.

Background

Noggin (1D2): The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]

Tag

Free

Gene ID

9241

Synonyms
SYM1; SYNS1.
Molecular Weight

Predicted band size: 26 kDa

Purity

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Research Field

Stem Cells

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Clonality

Monoclonal

Host

Mouse

Reactivity

Human, Mouse, Rat

SwissProt ID

Q13253

Dilution Ratio

WB: 1:500-1:1,000 ;IF: 1:50-1:200

Application

WB, ICC/IF

Appearance

Liquid

Formulation

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG3

Sensitivity

Transfected

Immunogen

Synthetic peptide corresponding to Human Noggin.The exact sequence is proprietary to MCE.

Documentation

Noggin Antibody (YA698) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Noggin Antibody (YA698)
Cat. No.:
HY-P80767
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