2. Anti-infection
  3. HCV
  4. Antiviral agent 52

Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM.

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Antiviral agent 52 Chemical Structure

Antiviral agent 52 Chemical Structure

CAS No. : 101784-44-5

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Antiviral agent 52 Related Antibodies

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Description

Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM[1].

In Vivo

Antiviral agent 52 (10 mg/kg, i.p.) is preferentially in liver distributed without significant hepatotoxicity[1].

Pharmacokinetic Analysis of Antiviral agent 52 in CD-1 mouse[1]

- plasma liver liver/plasma
AUClast (μM·h) 27.5 429 16
AUCINF (μM·h) 29.8 495 17
T1/2 (h) 6.7 8.5 -
Tmax (h) 0.083 0.083 -
Cmax (h) 5.28 57.0 11

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

335.27

Formula

C18H20Cl2N2
CAS No.
SMILES

CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiviral agent 52 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 52101784-44-5Antiviral agent52Antiviral agent-52HCVHepatitis C virushepatitis CInhibitorinhibitorinhibit

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