2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. AP1153 aptamer sodium

AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo.

For research use only. We do not sell to patients.

DNA, 5'-CATGGTGCAGGTGTGGCTGGGATTCATTTGCCGGTGCTGGTGCGTCCGCGGCCGCTAATCCTGTTC-3', sodium salt

AP1153 aptamer sodium Chemical Structure

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AP1153 aptamer sodium Related Antibodies

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Description

AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo[1].

IC50 & Target

Kd: ~15 pM (CCKBR)[1]
SMILES

[AP1153 aptamer (sodium)]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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AP1153 aptamer sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP1153 aptamerCholecystokinin ReceptorCCK ReceptorDNA aptamerpancreatic cancertargeted nanoparticlestumor imagingInhibitorinhibitorinhibit

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