APC-6860

Cat. No.: HY-114015: FAQs
Data Sheet Handling Instructions

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APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer.

For research use only. We do not sell to patients.

APC-6860 Chemical Structure

CAS No. : 154628-42-9

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Description

IC₅₀ & Target^[1]^[2]

uPA

0.21 μM (Ki)

trypsin

0.44 μM (Ki)

tryptase

1.5 μM (Ki)

tPA

16.8 μM (Ki)

thrombin

20 μM (Ki)

factor Xa

30 μM (Ki)

human urokinases

0.1 μM (Ki)

murine urokinases

0.082 μM (Ki)

In Vitro

APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC₅₀s of 1.4 and 3.1 μM, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

302.13

Formula

C₉H₇IN₂S

CAS No.

154628-42-9

SMILES

N=C(C1=CC2=C(I)C=CC=C2S1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. [Content Brief]

[2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001 Aug 7;40(31):9125-31. [Content Brief]

APC-6860 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APC-6860154628-42-9APC6860APC 6860Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesuPAtrypsintryptasetPAthrombinfactor XaInhibitorinhibitorinhibit

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