2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. ARB-272572

ARB-272572 is a potent small-molecule PD-L1 inhibitor with an IC50 value of 400 pM.

For research use only. We do not sell to patients.

ARB-272572 Chemical Structure

ARB-272572 Chemical Structure

CAS No. : 2368182-63-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 500 In-stock
Solution
10 mM * 1 mL in DMSO USD 500 In-stock
Solid
1 mg USD 200 In-stock
5 mg USD 400 In-stock
10 mg USD 600 In-stock
25 mg USD 1000 In-stock
50 mg USD 1480 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

ARB-272572 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ARB-272572 is a potent small-molecule PD-L1 inhibitor with an IC50 value of 400 pM.

Molecular Weight

568.67

Formula

C32H36N6O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C=CC=C1C2=CC=CC(NC(C3=NC=C(C=C3)CNCCO)=O)=C2C)NC(C4=CC=C(C=N4)CNCCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (219.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7585 mL 8.7924 mL 17.5849 mL
5 mM 0.3517 mL 1.7585 mL 3.5170 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.85%

COA (242 KB) HNMR (298 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7585 mL 8.7924 mL 17.5849 mL 43.9622 mL
5 mM 0.3517 mL 1.7585 mL 3.5170 mL 8.7924 mL
10 mM 0.1758 mL 0.8792 mL 1.7585 mL 4.3962 mL
15 mM 0.1172 mL 0.5862 mL 1.1723 mL 2.9308 mL
20 mM 0.0879 mL 0.4396 mL 0.8792 mL 2.1981 mL
25 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.7585 mL
30 mM 0.0586 mL 0.2931 mL 0.5862 mL 1.4654 mL
40 mM 0.0440 mL 0.2198 mL 0.4396 mL 1.0991 mL
50 mM 0.0352 mL 0.1758 mL 0.3517 mL 0.8792 mL
60 mM 0.0293 mL 0.1465 mL 0.2931 mL 0.7327 mL
80 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5495 mL
100 mM 0.0176 mL 0.0879 mL 0.1758 mL 0.4396 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ARB-272572 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARB-2725722368182-63-0ARB272572ARB 272572PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ARB-272572
Cat. No.:
HY-142221
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.