1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Arbutamine hydrochloride

Arbutamine hydrochloride is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine hydrochloride stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine hydrochloride provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine hydrochloride can be used for cardiac stress agent .

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Arbutamine hydrochloride Chemical Structure

Arbutamine hydrochloride Chemical Structure

CAS No. : 125251-66-3

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Description

Arbutamine hydrochloride is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine hydrochloride stimulates cardiac β1-, tracheal β2-, and adiopocyte β3- adrenergic receptors. Arbutamine hydrochloride provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine hydrochloride can be used for cardiac stress agent [1][2][3].

In Vitro

Arbutamine hydrochloride (0.1-100 nM) increases heart contractile force and pD2 value of 8.45. Arbutamine has the affinity constants (KA) value of 7.32 for cardiac β1-adrenergic receptors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Arbutamine hydrochloride (i.v.; 5, 10, 50, 100 and 250 ng/kg) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.84

Formula

C18H24ClNO4

CAS No.
SMILES

OC1=CC=C([C@@H](O)CNCCCCC2=CC=C(O)C=C2)C=C1O.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Arbutamine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Arbutamine hydrochloride
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HY-16056A
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