2. Neuronal Signaling Membrane Transporter/Ion Channel
  3. Serotonin Transporter Sodium Channel
  4. Atomoxetine

Atomoxetine  (Synonyms: Tomoxetine; (R)-Tomoxetine)

Cat. No.: HY-107370
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Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Atomoxetine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Atomoxetine Chemical Structure

Atomoxetine Chemical Structure

CAS No. : 83015-26-3

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Atomoxetine Related Antibodies

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Description

Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

In Vitro

Atomoxetine (Tomoxetine) (1-100 µM; 0.5-20 seconds; tsA201 cells) interacts with the human heart muscle sodium channel (hNav1.5) in a state and dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Atomoxetine Related Antibodies
In Vivo

Atomoxetine (Tomoxetine) (0.3-3 mg/kg; i.p.; 0-4 hours; male Sprague-Dawley rats) increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression in the rat prefrontal cortex[1].
Atomoxetine (Tomoxetine) (0.1-5 mg/kg; i.p. and p.o; for 14 days; spontaneously hypertensive rat) can improve behaviors associated with ADHD in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.3, 1 and 3 mg/kg
Administration: Intraperitoneal injection; for 4 hours
Result: Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.
Animal Model: Spontaneously hypertensive rat (SHR)[3]
Dosage: 0.1, 0.3, 1.25 and 5.0 mg/kg
Administration: Intraperitoneal injection and oral administration; for 14 days
Result: Had non-impact on the measurement of motor activity.
Clinical Trial
Molecular Weight

255.35

Formula

C17H21NO
CAS No.
SMILES

CC(C=CC=C1)=C1O[C@@H](C2=CC=CC=C2)CCNC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Atomoxetine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atomoxetine83015-26-3Tomoxetine (R)-TomoxetineSerotonin TransporterSodium Channel5-HTTSERTSLC6A4Na channelsNa+ channelsVGSCsnoradrenalinecatecholaminergicdopamineserotoninInhibitorinhibitorinhibit

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