Benztropine (Synonyms: Benzatropine; Benzotropine)

Cat. No.: HY-B0520: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects.

For research use only. We do not sell to patients.

Benztropine Chemical Structure

CAS No. : 86-13-5

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Benztropine:

Other Forms of Benztropine:

Benztropine mesylate In-stock

4 Publications Citing Use of MCE Benztropine

: Benztropine purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2018 Sep 11;12:309. [Abstract]; p38MAPK activation by dopamine (DA) can be inhibited by selective DAT blockers (Benztropine and Vanoxerine; 2 μM each) and PMAT blocker (Decynium; 2 μM). Combination of DAT and PMAT blockers further inhibits the activation of p38MAPK.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms

Biological Activity
Purity & Documentation
References
Customer Review

Description

Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research^[1]. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects^[2].

In Vitro

Benztropine (0.1-10 μM; 72 h) inhibits the growth of MDA-MB-231 cells with an IC₅₀ value about 5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine reduces the size as well as the number of mammospheres significantly in a dose-dependent manne^[1].
Benztropine inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors^[1].
Benztropine induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced remyelination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231
Concentration:	0, 0.1, 0.625, 1.25, 2.5, 5, 10 μM
Incubation Time:	72 hours
Result:	Inhibited cells growth of MDA-MB-231 with an IC₅₀ value about 5.0 μM.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-231
Concentration:	0, 1, 2, 5 μM
Incubation Time:	4-6 days
Result:	Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.

In Vivo

Benztropine (5 μM, 4 weeks) inhibits tumor-initiating potential in a 4T1 mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c mice bearing 4T1 breast tumors^[1]
Dosage:	1.5 mg/kg
Administration:	Injection; 3 weeks
Result:	Reduced the tumor size and weight significantly without body weight changing.

Clinical Trial

Molecular Weight

307.43

Formula

C₂₁H₂₅NO

CAS No.

86-13-5

SMILES

CN1[C@H]2CC(OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@@H]1CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022. [Content Brief]

[2]. Santosh S Kulkarni, et al. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorg Med Chem. 2006 Jun 1;14(11):3625-34. [Content Brief]

Benztropine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benztropine86-13-5Benzatropine BenzotropineDopamine ReceptormAChRHistamine ReceptorMuscarinic acetylcholine receptorParkinson'sdiseaseanticholinergicdopaminetransporteranti-histamineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks