2. Epigenetics
  3. Epigenetic Reader Domain
  4. BET-IN-15

BET-IN-15 (compound 1) is a potent and orally active BET inhibitor with IC50 values of 0.64, 0.25 nM for BRD4-BD1, BRD4-BD2, respectively. BET-IN-15 shows antiproliferative activity.

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BET-IN-15 Chemical Structure

BET-IN-15 Chemical Structure

CAS No. : 2408994-22-7

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BET-IN-15 Related Antibodies

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Description

BET-IN-15 (compound 1) is a potent and orally active BET inhibitor with IC50 values of 0.64, 0.25 nM for BRD4-BD1, BRD4-BD2, respectively. BET-IN-15 shows antiproliferative activity[1].

IC50 & Target[1]

BRD4-BD1

0.64 nM (IC50)

BRD4-BD2

0.25 nM (IC50)

In Vitro

BET-IN-15 (compound 1) (72 h) shows antiproliferative activity with IC50s of 3.14, 1.56 nM for MV4-11, Kasumi-1 cellS, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BET-IN-15 Related Antibodies
In Vivo

BET-IN-15 (compound 1) (72 h) 显示出抗增殖活性，对于 MV4-11、Kasumi-1 细胞的IC50s 分别为 3.14、1.56 nM[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

444.45

Formula

C21H18F2N4O3S
CAS No.
SMILES

O=C1C2=C(C(C3=C(OC4=CC=C(C=C4F)F)C=CC(N=S(C)(C)=O)=N3)=CN1C)C=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BET-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BET-IN-152408994-22-7Epigenetic Reader DomainInhibitorinhibitorinhibit

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BET-IN-15
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HY-153945
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