Disintegrin and metalloproteinase domain-containing protein 30

Definition:

Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation.

References:

[1]. Florent Letronne, et al. ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease. EBioMedicine. 2016 Jul;9:278-292. [Content Brief]

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