Parathyroid hormone type 1 receptor (PTHR1)

Definition:

Parathyroid hormone type 1 receptor (PTHR1), a class B G-protein-coupled receptor, is critical for calcium homeostasis and is a therapeutic target for osteoporosis and hypoparathyroidism.PTHR1 affects cell viability, apoptosis, migration, invasion and colony formation, possibly by regulating AGT/CCL9 in osteosarcoma (OS) cells.

References:

[1]. Zhao LH, et al. Structure and dynamics of the active human parathyroid hormone receptor-1. Science. 2019 Apr 12;364(6436):148-153. [Content Brief]

[2]. Li S, et al. Parathyroid hormone type 1 receptor regulates osteosarcoma K7M2 Cell growth by interacting with angiotensinogen. J Cell Mol Med. 2021 Mar;25(6):2841-2850. [Content Brief]

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