Potassium voltage-gated channel subfamily H member 1

Definition:

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs).

References:

[1]. Roland Schönherr, et al. Functional distinction of human EAG1 and EAG2 potassium channels. FEBS Lett. 2002 Mar 13;514(2-3):204-8. [Content Brief]

[2]. R Schönherr, et al. Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. EMBO J. 2000 Jul 3;19(13):3263-71. [Content Brief]

[3]. T Occhiodoro, et al. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett. 1998 Aug 28;434(1-2):177-82. [Content Brief]

[4]. Maria João Marques-Carvalho, et al. Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel. Structure. 2016 Oct 4;24(10):1742-1754. [Content Brief]

[5]. Bo Han, et al. Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Sci Rep. 2016 Mar 23;6:23417. [Content Brief]

[6]. Ying-Ying Zhang, et al. BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2014 Feb;229(2):202-12. [Content Brief]

[7]. Lena Sünke Mortensen, et al. KV 10.1 opposes activity-dependent increase in Ca²⁺ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. J Physiol. 2015 Jan 1;593(1):181-96. [Content Brief]

[8]. Maria J Marques-Carvalho, et al. Structural, biochemical, and functional characterization of the cyclic nucleotide binding homology domain from the mouse EAG1 potassium channel. J Mol Biol. 2012 Oct 12;423(1):34-46. [Content Brief]

[9]. Eva Lörinczi, et al. Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain. J Biol Chem. 2016 Aug 19;291(34):17907-18. [Content Brief]

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