Pre-B-cell leukemia transcription factor-interacting protein 1

Definition:

Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.

References:

[1]. Bramanandam Manavathi, et al. An inherent role of microtubule network in the action of nuclear receptor. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15981-6. [Content Brief]

[2]. C Abramovich, et al. Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA. J Biol Chem. 2000 Aug 25;275(34):26172-7. [Content Brief]

[3]. Carolina Abramovich, et al. Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP). Oncogene. 2002 Oct 3;21(44):6766-71. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.