Pre-mRNA-splicing factor SLU7

Definition:

Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

References:

[1]. Xiaofeng Zhang, et al. An Atomic Structure of the Human Spliceosome. Cell. 2017 May 18;169(5):918-929.e14. [Content Brief]

[2]. K Chua, et al. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. Nature. 1999 Nov 11;402(6758):207-10. [Content Brief]

[3]. Galit Lev-Maor, et al. The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons. Science. 2003 May 23;300(5623):1288-91. [Content Brief]

[4]. Noam Shomron, et al. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. J Cell Sci. 2005 Mar 15;118(Pt 6):1151-9. [Content Brief]

[5]. Noam Shomron, et al. Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. Mol Biol Cell. 2004 Aug;15(8):3782-95. [Content Brief]

[6]. K Chua, et al. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Genes Dev. 1999 Apr 1;13(7):841-50. [Content Brief]

[7]. Sebastian M Fica, et al. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 Feb 15;363(6428):710-714. [Content Brief]

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