Prostate stem cell antigen

Definition:

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

References:

[1]. Majbrit M Jensen, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015 Apr;36(4):1629-1638. [Content Brief]

[2]. Study Group of Millennium Genome Project for Cancer, et al. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet. 2008 Jun;40(6):730-40. [Content Brief]

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