Proteasome assembly chaperone 1

Definition:

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

References:

[1]. Yuko Hirano, et al. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature. 2005 Oct 27;437(7063):1381-5. [Content Brief]

[2]. Benoît Le Tallec, et al. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol Cell. 2007 Aug 17;27(4):660-74. [Content Brief]

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