Protein CLEC16A

Definition:

Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.

References:

[1]. Scott A Soleimanpour, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell. 2014 Jun 19;157(7):1577-90. [Content Brief]

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