SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Definition:

ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.

References:

[1]. Timur Yusufzai, et al. HARP is an ATP-driven annealing helicase. Science. 2008 Oct 31;322(5902):748-50. [Content Brief]

[2]. Carol E Bansbach, et al. The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Genes Dev. 2009 Oct 15;23(20):2405-14. [Content Brief]

[3]. Alberto Ciccia, et al. The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 2009 Oct 15;23(20):2415-25. [Content Brief]

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