Transmembrane protein 39A

Definition:

Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools. Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L.; (Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway.

References:

[1]. Xiangrong Li, et al. Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis Virus via Autophagy Pathway. Front Microbiol. 2019 Nov 29;10:2680. [Content Brief]

[2]. Guangyan Miao, et al. The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1. Mol Cell. 2020 Feb 6;77(3):618-632.e5. [Content Brief]

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