Transmembrane protein 8B

Definition:

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.

References:

[1]. Shuping Peng, et al. The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. Cancer Sci. 2007 Mar;98(3):341-9. [Content Brief]

[2]. Jian Ma, et al. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Carcinogenesis. 2005 Feb;26(2):281-91. [Content Brief]

[3]. Lili Wang, et al. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. J Cell Biochem. 2005 May 1;95(1):64-73. [Content Brief]

[4]. Shu-Ping Peng, et al. The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. Oncology. 2006;71(3-4):273-81. [Content Brief]

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