Type-2 angiotensin II receptor

Definition:

Receptor for angiotensin II, a vasoconstricting peptide. Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

References:

[1]. Haitao Zhang, et al. Structural basis for selectivity and diversity in angiotensin II receptors. Nature. 2017 Apr 20;544(7650):327-332. [Content Brief]

[2]. Hidetsugu Asada, et al. The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. Structure. 2020 Apr 7;28(4):418-425.e4. [Content Brief]

[3]. Hidetsugu Asada, et al. Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nat Struct Mol Biol. 2018 Jul;25(7):570-576. [Content Brief]

[4]. S Tsuzuki, et al. Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1994 May 16;200(3):1449-54. [Content Brief]

[5]. Sandrine Nouet, et al. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem. 2004 Jul 9;279(28):28989-97. [Content Brief]

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