Biotin-NH-PSMA-617

Name: Biotin-NH-PSMA-617
Brand: MedChemExpress
SKU: HY-141729
Rating: 4.5 (1 reviews)

Cat. No.: HY-141729 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Biotin-NH-PSMA-617 is a biotin-tagged PSMA-617. PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA), which is directly expressed by the tumor cells .

For research use only. We do not sell to patients.

Biotin-NH-PSMA-617 Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Biotin-NH-PSMA-617 is a biotin-tagged PSMA-617. PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA), which is directly expressed by the tumor cells ^[1].

In Vitro

PSMA-617 is a PSMA ligand. PSMA-617 shows a significantly improved binding affinity to PSMA as well as a highly efficient internalization into PCa cells. PSMA-617 can be labeled with ⁶⁸Ga, ¹⁷⁷Lu, ¹¹¹In, and ⁹⁰Y and, therefore, be used for PET-imaging as well as for radioligand-based therapy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1396.61

Formula

C₆₅H₉₇N₁₃O₁₉S

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CCCCNC([C@@H](CC1=CC=C2C=CC=CC2=C1)NC(C3CCC(CNC([C@@H](NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)CCCCNC(CCCC[C@@H]5SC[C@]([C@]5([H])N6)([H])NC6=O)=O)=O)CC3)=O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (35.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7160 mL	3.5801 mL	7.1602 mL
5 mM	0.1432 mL	0.7160 mL	1.4320 mL
10 mM	0.0716 mL	0.3580 mL	0.7160 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.07%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) RP-HPLC (101 KB) MS (111 KB)

Handling Instructions (2659 KB)

References

[1]. Kratochwil C, et al. Targeted alpha therapy of mCRPC: Dosimetry estimate of 213Bismuth-PSMA-617. Eur J Nucl Med Mol Imaging. 2018;45(1):31-37. [Content Brief]

[2]. Afshar-Oromieh A, et al. The Theranostic PSMA Ligand PSMA-617 in the Diagnosis of Prostate Cancer by PET/CT: Biodistribution in Humans, Radiation Dosimetry, and First Evaluation of Tumor Lesions. J Nucl Med. 2015;56(11):1697-1705. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7160 mL	3.5801 mL	7.1602 mL	17.9005 mL
	5 mM	0.1432 mL	0.7160 mL	1.4320 mL	3.5801 mL
	10 mM	0.0716 mL	0.3580 mL	0.7160 mL	1.7900 mL
	15 mM	0.0477 mL	0.2387 mL	0.4773 mL	1.1934 mL
	20 mM	0.0358 mL	0.1790 mL	0.3580 mL	0.8950 mL
	25 mM	0.0286 mL	0.1432 mL	0.2864 mL	0.7160 mL
	30 mM	0.0239 mL	0.1193 mL	0.2387 mL	0.5967 mL