2. Cell Cycle/DNA Damage
  3. CDK
  4. BLU-222

BLU-222 is an orally effective and selective CDK2 inhibitor. BLU-222 has antitumor activity.

For research use only. We do not sell to patients.

BLU-222 Chemical Structure

BLU-222 Chemical Structure

CAS No. : 2888704-84-3

Size Price Stock Quantity
5 mg USD 370 In-stock
10 mg USD 640 In-stock
25 mg USD 1280 In-stock
50 mg USD 2250 In-stock
100 mg USD 3950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BLU-222 is an orally effective and selective CDK2 inhibitor. BLU-222 has antitumor activity[1].

Molecular Weight

365.34

Formula

C15H17F2N7O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC(OC1=CC(NC2=NC3=C(C=NN3CC4CCOCC4)N=C2)=NN1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (273.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7372 mL 13.6859 mL 27.3718 mL
5 mM 0.5474 mL 2.7372 mL 5.4744 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7372 mL 13.6859 mL 27.3718 mL 68.4294 mL
5 mM 0.5474 mL 2.7372 mL 5.4744 mL 13.6859 mL
10 mM 0.2737 mL 1.3686 mL 2.7372 mL 6.8429 mL
15 mM 0.1825 mL 0.9124 mL 1.8248 mL 4.5620 mL
20 mM 0.1369 mL 0.6843 mL 1.3686 mL 3.4215 mL
25 mM 0.1095 mL 0.5474 mL 1.0949 mL 2.7372 mL
30 mM 0.0912 mL 0.4562 mL 0.9124 mL 2.2810 mL
40 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7107 mL
50 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3686 mL
60 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1405 mL
80 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8554 mL
100 mM 0.0274 mL 0.1369 mL 0.2737 mL 0.6843 mL
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BLU-222 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLU-2222888704-84-3BLU222BLU 222CDKCyclin dependent kinaseCDK2AntitumorInhibitorinhibitorinhibit

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