2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF) Apoptosis Mitochondrial Metabolism
  4. BTM-3528

BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells.

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BTM-3528 Chemical Structure

BTM-3528 Chemical Structure

CAS No. : 2054998-45-5

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BTM-3528 Related Antibodies

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Description

BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells[1].

Molecular Weight

521.55

Formula

C24H19F4N3O2S2
CAS No.
SMILES

CC(C)SC1=C(C2=CC=C(C(F)(F)F)C=C2)N=C(N3N=C(C)C(C4=CC(F)=CC=C4)=C3C(O)=O)S1
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BTM-3528 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTM-35282054998-45-5BTM3528BTM 3528Eukaryotic Initiation Factor (eIF)ApoptosisMitochondrial MetabolismOMA1Inhibitorinhibitorinhibit

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