2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. CBiPES hydrochloride

CBiPES hydrochloride is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease.

For research use only. We do not sell to patients.

CBiPES hydrochloride Chemical Structure

CBiPES hydrochloride Chemical Structure

CAS No. : 856702-40-4

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Based on 1 publication(s) in Google Scholar

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CBiPES hydrochloride Related Antibodies

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Description

CBiPES hydrochloride is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease[1][2].

IC50 & Target

EC50: 92.8 nM (mGlu2 receptor)[1]
Molecular Weight

413.92

Formula

C21H20ClN3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCS(N(C1=CC(C2=CC=C(C#N)C=C2)=CC=C1)CC3=CN=CC=C3)(=O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (301.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4159 mL 12.0796 mL 24.1593 mL
5 mM 0.4832 mL 2.4159 mL 4.8319 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4159 mL 12.0796 mL 24.1593 mL 60.3981 mL
5 mM 0.4832 mL 2.4159 mL 4.8319 mL 12.0796 mL
10 mM 0.2416 mL 1.2080 mL 2.4159 mL 6.0398 mL
15 mM 0.1611 mL 0.8053 mL 1.6106 mL 4.0265 mL
20 mM 0.1208 mL 0.6040 mL 1.2080 mL 3.0199 mL
25 mM 0.0966 mL 0.4832 mL 0.9664 mL 2.4159 mL
30 mM 0.0805 mL 0.4027 mL 0.8053 mL 2.0133 mL
40 mM 0.0604 mL 0.3020 mL 0.6040 mL 1.5100 mL
50 mM 0.0483 mL 0.2416 mL 0.4832 mL 1.2080 mL
60 mM 0.0403 mL 0.2013 mL 0.4027 mL 1.0066 mL
80 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7550 mL
100 mM 0.0242 mL 0.1208 mL 0.2416 mL 0.6040 mL
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CBiPES hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBiPES856702-40-4mGluRMetabotropic glutamate receptorspsychiatrichyperthermiahyperlocomotorstressParkinson’sInhibitorinhibitorinhibit

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