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  4. Cholest-5-ene-3ß,22(S)-diol

Cholest-5-ene-3ß,22(S)-diol  (Synonyms: (22S)-Hydroxycholesterol)

Cat. No.: HY-137307
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Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models.

For research use only. We do not sell to patients.

Cholest-5-ene-3ß,22(S)-diol Chemical Structure

Cholest-5-ene-3ß,22(S)-diol Chemical Structure

CAS No. : 22348-64-7

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Based on 1 publication(s) in Google Scholar

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Cholest-5-ene-3ß,22(S)-diol Related Antibodies

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Description

Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].

In Vitro

Cholest-5-ene-3ß,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) shows no effect on phosphatidylserine externalization, mitochondrial transmembrane potential, cellular permeability to propidium iodide, and morphological nuclear changes in U937 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholest-5-ene-3ß,22(S)-diol Related Antibodies
In Vivo

Cholest-5-ene-3ß,22(S)-diol (30 mg/kg; p.o.; added in diet, treated for 3 weeks) reduces body weight gain and abolishes high-fat diet-induced increase of triacylglycerol (TAG) levels in serum[2].

Pharmacokinetic Analysis in Rats[2]

Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) AUCt (ng·h/mL) AUC (ng·h/mL) T1/2 (h) Extent of tritium exchange (%)
i.v. 50 22.4 0.08 174 195 8.1 2.8
p.o. 50 7.5 4 95.2 104 6.4 1.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2]
Dosage: 30 mg/kg/day
Administration: Oral gavage; 3 weeks consecutively
Result: Decreased body weight gain significantly after 1 week treatment.
Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.
Molecular Weight

402.65

Formula

C27H46O2
CAS No.
SMILES

C[C@]12[C@](CC[C@]1([H])[C@H](C)[C@@H](O)CCC(C)C)([H])[C@@](CC=C3C[C@H]4O)([H])[C@@](CC2)([H])[C@]3(CC4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cholest-5-ene-3ß,22(S)-diol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholest-5-ene-3ß,22(S)-diol22348-64-7(22S)-HydroxycholesterolOthersInhibitorinhibitorinhibit

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