Dehydroevodiamine

Cat. No.: HY-N2106 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

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Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.

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Dehydroevodiamine Chemical Structure

CAS No. : 67909-49-3

Size	Price	Stock	Quantity
5 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Dehydroevodiamine:

Dehydroevodiamine hydrochloride In-stock

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Description

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes^[1]. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells^[2].

IC₅₀ & Target

iNOS; COX-2; PGE2; NF-κB^[2]

In Vitro

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages^[2].
Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR^[2]

Cell Line:	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 mRNA expression.

Molecular Weight

301.34

Formula

C₁₉H₁₅N₃O

CAS No.

67909-49-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N2C(C([N-]C3=C4C=CC=C3)=C4CC2)=[N+](C)C5=C1C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL (27.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3185 mL	16.5926 mL	33.1851 mL
5 mM	0.6637 mL	3.3185 mL	6.6370 mL
10 mM	0.3319 mL	1.6593 mL	3.3185 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.96%

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Data Sheet (250 KB) SDS (0 KB)

COA (253 KB) HNMR (105 KB) RP-HPLC (102 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3185 mL	16.5926 mL	33.1851 mL	82.9628 mL
	5 mM	0.6637 mL	3.3185 mL	6.6370 mL	16.5926 mL
	10 mM	0.3319 mL	1.6593 mL	3.3185 mL	8.2963 mL
	15 mM	0.2212 mL	1.1062 mL	2.2123 mL	5.5309 mL
	20 mM	0.1659 mL	0.8296 mL	1.6593 mL	4.1481 mL
	25 mM	0.1327 mL	0.6637 mL	1.3274 mL	3.3185 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydroevodiamine67909-49-3Inhibitorinhibitorinhibit

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Dehydroevodiamine

Other Forms of Dehydroevodiamine: