DL-AP4  (Synonyms: 2-Amino-4-phosphonobutyric acid)

DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent K_d of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system^[1][2][3].

Glutamate^[1]

DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells^[1].
DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane^[2].
DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent K_d of 2.5 μM^[3].
DL-AP4 (50 µM; 0-2 seconds) blocks the light response of a series of 10 ms 405-nm flashes, at the following strengths: 3, 10, 30, 100, 300, 990, 3000, 9900 photons μm^-2[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

183.10

C₄H₁₀NO₅P

6323-99-5

O=C(O)C(N)CCP(O)(O)=O

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