2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Methyltransferase HIF/HIF Prolyl-Hydroxylase
  4. DYB-03

DYB-03 is an oral active HIF-1α/EZH2 inhibitor. DYB-03 inhibits migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo. DYB-03 induces apoptosis in 2-ME2- and GSK126-resistant of A549 and H460 cells.

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DYB-03 Chemical Structure

DYB-03 Chemical Structure

CAS No. : 2982792-85-6

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Description

DYB-03 is an oral active HIF-1α/EZH2 inhibitor. DYB-03 inhibits migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo. DYB-03 induces apoptosis in 2-ME2- and GSK126-resistant of A549 and H460 cells[1].

Molecular Weight

479.56

Formula

C28H33NO6
CAS No.
SMILES

COC1=CC=C(/C=C/C(C2=CC=C(OC(C)(C)C=C3)C3=C2O)=O)C=C1OCCCN4CCOCC4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DYB-03 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYB-032982792-85-6DYB03DYB 03Histone MethyltransferaseHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHUVEClung cancer cellscell apoptosisInhibitorinhibitorinhibit

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