2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Apoptosis
  3. EGFR Apoptosis
  4. EGFR-IN-108 chloride

EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects.

For research use only. We do not sell to patients.

EGFR-IN-108 chloride Chemical Structure

EGFR-IN-108 chloride Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

EGFR-IN-108 chloride Related Antibodies

Top Publications Citing Use of Products

View All EGFR Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EGFR-IN-108 chloride (Compound Ru3S) is an EGFR inhibitor with an IC50 value of 5.8 nM for hEGFR. EGFR-IN-108 chloride induces apoptosis and has anti-proliferative activity against cancer cells. EGFR-IN-108 chloride also has anti-angiogenic effects[1].

In Vitro

Ru4S (0.2-100 μM; 48 h) shows cytotoxicity on HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells, with IC50 values of 23.76, 2.47, 6.24, 5.35, 29.90, 33.15 μM respectively[1].
Ru4S (0.78-50 μM; 48 h) induces apoptosis in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-108 chloride Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, Caco-2, HT-29, MCF-7, A549, HEK293T cells
Concentration: 0.2-100 μM
Incubation Time: 48 h
Result: exhibited cytotoxicity.

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 0.78, 3.12, 12.5, and 50 μM
Incubation Time: 48 h
Result: increased Sub G1 (p < 0.0001) and decreased G0/G1, S, and G2/M percentages (p < 0.05) at 0.78 μM. And slightly increased Sub G1 (p < 0.01), slightly decreased G0/G1 (p < 0.01), and decreased G2/M (p < 0.05) at 3.12 and 12.5 μM. Increased Sub G1(p < 0.0001) and decreased S (p < 0.01), and did not affect the G0/G1 and G2/M phases at 50 μM.
Molecular Weight

1005.28

Formula

C45H40Cl3F3N8O3Ru
SMILES

CC1=[N]2[Ru+2]3([N]4=C(C)C=CC=C4C5=CC=CC(C)=[N]35)([N]6=CC=C(OC7=CC=C(NC(NC8=CC=C(Cl)C(C(F)(F)F)=C8)=O)C=C7)C=C6C9=O)([NH]9C)[N]%10=C(C)C=CC=C%10C2=CC=C1.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

EGFR-IN-108 chloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-108EGFRApoptosisEpidermal growth factor receptorErbB-1HER1HepG2 cellsCaco-2 cellsHT-29 cellsMCF-7 cellscytotoxicitycell cycleInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
EGFR-IN-108 chloride
Cat. No.:
HY-163402
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.