Eletriptan (Synonyms: UK-116044)

Cat. No.: HY-A0039: FAQs
Data Sheet Handling Instructions

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Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT_1B and 5-HT_1D receptor agonist, with pK_i values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Eletriptan hydrobromide) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Eletriptan Chemical Structure

CAS No. : 143322-58-1

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References
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Description

IC₅₀ & Target^[1]

5-HT_1B Receptor

8.0 (pKi)

5-HT_1D Receptor

8.9 (pKi)

In Vivo

Eletriptan (10, 30, 100, 300 and 1000 µg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

382.52

Formula

C₂₂H₂₆N₂O₂S

CAS No.

143322-58-1

SMILES

CN1[C@@H](CC2=CNC3=CC=C(CCS(C4=CC=CC=C4)(=O)=O)C=C32)CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49. [Content Brief]

[2]. Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):212-9. [Content Brief]

Eletriptan Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eletriptan143322-58-1UK-116044UK116044UK 1160445-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1Dmigraineneurogenic inflammationcarotid blood floworally activeInhibitorinhibitorinhibit

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