2. Anti-infection
  3. Parasite
  4. ELQ-598

ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis.

For research use only. We do not sell to patients.

ELQ-598 Chemical Structure

ELQ-598 Chemical Structure

CAS No. : 3023709-99-8

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Description

ELQ-598, as a prodrug, is converted into the active drug ELQ-596 upon oral administration. ELQ-598 demonstrates potent parasitic growth inhibition capabilities (IC50= 37 nM). ELQ-598 also shows low toxicity towards human cells (IC50= 19 μM). ELQ-598 can be used for research into babesiosis[1].

In Vivo

ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) achieves complete elimination of B. duncani infection in C3H mice[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) is effective at eliminating B. microti infection in mice[1].
ELQ-598 (10 mg/kg; p.o.; daily DPI 3-7) combined with atovaquone (HY-13832) can eliminative of the infection in the C3H/HeJ mice infected with B. duncani and SCID mice model infected with B. microti[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H mice genetically prone to B. duncani infection[1]
Dosage: 10mg/kg
Administration: p.o.; daily DPI 3-7
Result: Resulted in a complete elimination of the parasites. Mice survived for the duration of the study with no recurrence of parasitemia observed.
Animal Model: C3H/HeJ mice for B. duncani infection, and SCID mice for B. microti infection[1]
Dosage: 10mg/kg with 10mg/kg atovaquone,
Administration: p.o.; daily DPI 3-7
Result: All mice survived without any recurrence of parasitemia.
A potent synergistic or additive effect of the drug combination in eradicating the lethal infection.This combination strategy offers enhanced efficacy compared to the use of either compound alone.
Molecular Weight

561.93

Formula

C28H23ClF3NO6
CAS No.
SMILES

ClC1=CC2=C(N=C(C)C(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C3)=C2OCOC(OCC)=O)C=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ELQ-598 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELQ-5983023709-99-8ELQ598ELQ 598ParasiteAntiparasiticProdrug of ELQ-596BabesiosisMitochondrial Cytochrome bc1 InhibitorC3H miceSCID miceInhibitorinhibitorinhibit

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