2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. ERK Apoptosis
  4. Enniatin A1

Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes.

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Enniatin A1 Chemical Structure

Enniatin A1 Chemical Structure

CAS No. : 4530-21-6

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Description

Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes[1].

IC50 & Target[1]

ERK

 

Molecular Weight

667.87

Formula

C35H61N3O9
CAS No.
SMILES

O=C([C@@]([C@@H](C)CC)([H])N(C)C([C@@H](C(C)C)OC(C([C@@H](C)CC)N(C)C([C@@H](C(C)C)OC([C@H](C(C)C)N1C)=O)=O)=O)=O)O[C@@](C(C)C)([H])C1=O
Structure Classification
Initial Source

Fusarium tricinctum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Enniatin A1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enniatin A14530-21-6Enniatin A 1Enniatin A-1ERKApoptosisExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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