2. Epigenetics
  3. Histone Acetyltransferase
  4. Ep300/CREBBP-IN-4

Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer.

For research use only. We do not sell to patients.

Ep300/CREBBP-IN-4 Chemical Structure

Ep300/CREBBP-IN-4 Chemical Structure

CAS No. : 2259641-42-2

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Ep300/CREBBP-IN-4 Related Antibodies

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Description

Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer[1].

IC50 & Target[1]

EP300

0.024 μM (IC50)

CREBBP

0.064 μM (IC50)

In Vitro

Ep300/CREBBP-IN-4 (Example 56) inhibits intracellular H3K27Ac activity with an IC50 of 0.020 μM[1].
Ep300/CREBBP-IN-4 (38 nM-10 mM; 3 days) inhibits LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ep300/CREBBP-IN-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: LK2 and TE-8 cells
Concentration: 38 nM-10 mM
Incubation Time: 3 days
Result: Inhibited LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively.
Molecular Weight

473.45

Formula

C23H22F3N5O3
CAS No.
SMILES

O=C(N1[C@H](C[C@H](C1)F)C(NC2=CC=C(NN=C3)C3=N2)=O)C4(C5=CC=C(C=C5)OC)CC(F)(C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ep300/CREBBP-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ep300/CREBBP-IN-42259641-42-2Histone AcetyltransferaseHATsHATH3K27AcLK2TE-8Inhibitorinhibitorinhibit

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