CIROP - ciliated left-right organizer metallopeptidase Gene

Homo sapiens

Also known as HTX12; LMLN2

Gene ID: 100128908 | Gene type: protein coding

About CIROP

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,099,062-23,104,989 (from NCBI)

This gene has 4 transcripts (splice variants), 54 orthologues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

Predicted to enable peptidase activity. Predicted to be involved in cell adhesion and proteolysis. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CIROP Products(2)

mRNA	Protein	Name
NM_001354640.2	NP_001341569.1	ciliated left-right organizer metallopeptidase isoform 1 precursor
NM_001402427.1	NP_001389356.1	ciliated left-right organizer metallopeptidase isoform 2 precursor

Protein Preferred Names

Protein Names

ciliated left-right organizer metallopeptidase

leishmanolysin homolog

Related Diseases

Diseases

Alias

Heterotaxy, Visceral, 12, Autosomal

HTX12

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02722	CIROP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIROP	RGD	RGD:1560492
Canis familiaris	CIROP	VGNC	VGNC:108383
Macaca mulatta	CIROP	VGNC	VGNC:108382
Mus musculus	CIROP	MGD	MGI:5588935

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