2. Gene
  3. ABI2 - abl interactor 2 Gene

ABI2 - abl interactor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB

Gene ID: 10152 | Gene type: protein coding

About ABI2

Cytogenetic location: 2q33.2 Genomic coordinates (GRCh38): 2:203,328,394-203,432,169 (from NCBI)

This gene has 24 transcripts (splice variants), 201 orthologues and 2 paralogues. Broad expression in brain (RPKM 35.9), thyroid (RPKM 13.9) and 21 other tissues.

Summary

Enables several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including filopodium tip; lamellipodium; and nucleoplasm. Part of SCAR complex. Is active in adherens junction. Colocalizes with actin filament. [provided by Alliance of Genome Resources, Apr 2022]

ABI2 Products(88)

mRNA Protein Name
NM_001282925.3 NP_001269854.1 abl interactor 2 isoform a
NM_001282926.3 NP_001269855.1 abl interactor 2 isoform b
NM_001282927.2 NP_001269856.1 abl interactor 2 isoform d
NM_001282932.2 NP_001269861.1 abl interactor 2 isoform e
NM_001375662.1 NP_001362591.1 abl interactor 2 isoform f
NM_001375663.1 NP_001362592.1 abl interactor 2 isoform f
NM_001375664.1 NP_001362593.1 abl interactor 2 isoform g
NM_001375665.1 NP_001362594.1 abl interactor 2 isoform g
NM_001375666.1 NP_001362595.1 abl interactor 2 isoform h
NM_001375667.1 NP_001362596.1 abl interactor 2 isoform h
NM_001375668.1 NP_001362597.1 abl interactor 2 isoform i
NM_001375669.1 NP_001362598.1 abl interactor 2 isoform i
NM_001375670.1 NP_001362599.1 abl interactor 2 isoform j
NM_001375671.1 NP_001362600.1 abl interactor 2 isoform k
NM_001375672.1 NP_001362601.1 abl interactor 2 isoform l
NM_001375673.1 NP_001362602.1 abl interactor 2 isoform m
NM_001375674.1 NP_001362603.1 abl interactor 2 isoform n
NM_001375675.1 NP_001362604.1 abl interactor 2 isoform o
NM_001375676.1 NP_001362605.1 abl interactor 2 isoform p
NM_001375677.1 NP_001362606.1 abl interactor 2 isoform q
NM_001375678.1 NP_001362607.1 abl interactor 2 isoform r
NM_001375679.1 NP_001362608.1 abl interactor 2 isoform s
NM_001375680.1 NP_001362609.1 abl interactor 2 isoform t
NM_001375681.1 NP_001362610.1 abl interactor 2 isoform u
NM_001375682.1 NP_001362611.1 abl interactor 2 isoform v
NM_001375683.1 NP_001362612.1 abl interactor 2 isoform w
NM_001375684.1 NP_001362613.1 abl interactor 2 isoform x
NM_001375685.1 NP_001362614.1 abl interactor 2 isoform y
NM_001375686.1 NP_001362615.1 abl interactor 2 isoform z
NM_001375687.1 NP_001362616.1 abl interactor 2 isoform aa
NM_001375688.1 NP_001362617.1 abl interactor 2 isoform bb
NM_001375689.1 NP_001362618.1 abl interactor 2 isoform cc
NM_001375690.1 NP_001362619.1 abl interactor 2 isoform dd
NM_001375691.1 NP_001362620.1 abl interactor 2 isoform ee
NM_001375692.1 NP_001362621.1 abl interactor 2 isoform ff
NM_001375693.1 NP_001362622.1 abl interactor 2 isoform gg
NM_001375695.1 NP_001362624.1 abl interactor 2 isoform hh
NM_001375696.1 NP_001362625.1 abl interactor 2 isoform ii
NM_001375698.1 NP_001362627.1 abl interactor 2 isoform jj
NM_001375699.1 NP_001362628.1 abl interactor 2 isoform kk
NM_001375702.1 NP_001362631.1 abl interactor 2 isoform ll
NM_001375704.1 NP_001362633.1 abl interactor 2 isoform mm
NM_001375706.1 NP_001362635.1 abl interactor 2 isoform nn
NM_001375707.1 NP_001362636.1 abl interactor 2 isoform oo
NM_001375708.1 NP_001362637.1 abl interactor 2 isoform pp
NM_001375709.1 NP_001362638.1 abl interactor 2 isoform qq
NM_001375710.1 NP_001362639.1 abl interactor 2 isoform rr
NM_001375711.1 NP_001362640.1 abl interactor 2 isoform ss
NM_001375712.1 NP_001362641.1 abl interactor 2 isoform tt
NM_001375714.1 NP_001362643.1 abl interactor 2 isoform uu
NM_001375717.1 NP_001362646.1 abl interactor 2 isoform vv
NM_001375719.1 NP_001362648.1 abl interactor 2 isoform ww
NM_001375721.1 NP_001362650.1 abl interactor 2 isoform xx
NM_001375722.1 NP_001362651.1 abl interactor 2 isoform yy
NM_001375723.1 NP_001362652.1 abl interactor 2 isoform zz
NM_001375724.1 NP_001362653.1 abl interactor 2 isoform aaa
NM_001375725.1 NP_001362654.1 abl interactor 2 isoform bbb
NM_001375726.1 NP_001362655.1 abl interactor 2 isoform ccc
NM_001375727.1 NP_001362656.1 abl interactor 2 isoform ddd
NM_001375728.1 NP_001362657.1 abl interactor 2 isoform eee
NM_001375729.1 NP_001362658.1 abl interactor 2 isoform fff
NM_001375730.1 NP_001362659.1 abl interactor 2 isoform ggg
NM_001375731.1 NP_001362660.1 abl interactor 2 isoform hhh
NM_001375732.1 NP_001362661.1 abl interactor 2 isoform iii
NM_001375733.1 NP_001362662.1 abl interactor 2 isoform jjj
NM_001375734.1 NP_001362663.1 abl interactor 2 isoform kkk
NM_001375735.1 NP_001362664.1 abl interactor 2 isoform lll
NM_001375736.1 NP_001362665.1 abl interactor 2 isoform mmm
NM_001375737.1 NP_001362666.1 abl interactor 2 isoform nnn
NM_001375738.1 NP_001362667.1 abl interactor 2 isoform ooo
NM_001375739.1 NP_001362668.1 abl interactor 2 isoform ppp
NM_001375740.1 NP_001362669.1 abl interactor 2 isoform rrr
NM_001375741.1 NP_001362670.1 abl interactor 2 isoform sss
NM_001375742.1 NP_001362671.1 abl interactor 2 isoform ttt
NM_001375743.1 NP_001362672.1 abl interactor 2 isoform uuu
NM_001375744.1 NP_001362673.1 abl interactor 2 isoform vvv
NM_001375745.1 NP_001362674.1 abl interactor 2 isoform www
NM_001375746.1 NP_001362675.1 abl interactor 2 isoform xxx
NM_001375747.1 NP_001362676.1 abl interactor 2 isoform yyy
NM_001375748.1 NP_001362677.1 abl interactor 2 isoform zzz
NM_001375749.1 NP_001362678.1 abl interactor 2 isoform aaaa
NM_001375750.1 NP_001362679.1 abl interactor 2 isoform bbbb
NM_001375751.1 NP_001362680.1 abl interactor 2 isoform cccc
NM_001375752.1 NP_001362681.1 abl interactor 2 isoform dddd
NM_001375753.1 NP_001362682.1 abl interactor 2 isoform eeee
NM_001375754.1 NP_001362683.1 abl interactor 2 isoform d
NM_001375755.1 NP_001362684.1 abl interactor 2 isoform qqq
NM_005759.7 NP_005750.4 abl interactor 2 isoform c

ABI2 Protein Structure

Abi_HHR

Abi_HHR: Abl-interactor HHR (93 - 170)

SH3_9

SH3_9: Variant SH3 domain (458 - 506)

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  • 513 a.a.
Protein Preferred Names Protein Names

abl interactor 2

abelson interactor 2

Related Diseases

Diseases Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h

Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency

Muscular Dystrophy Hutterite Type

Sarcotubular Myopathy

Limb-Girdle Muscular Dystrophy Type 2h
Cataract 3, Multiple Types

Cataract 3 Multiple Types

CTRCT3

Cca2

Cataract, Congenital, Cerulean Type, 2

Cataract 3, Multiple Types, With Or Without Microcornea

Cataract 3 Multiple Types With Or Without Microcornea

Congenital Cerulean Type Cataract 2

Congenital Cataract Blue Dot Type 2

Congenital Cataract Cerulean Type 2

Cspc

Sutural Cataract With Punctate And Cerulean Opacities
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00099 ABI2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ABI2 VGNC VGNC:59487
Macaca mulatta ABI2 VGNC VGNC:69518
Canis familiaris ABI2 VGNC VGNC:37475
Bos taurus ABI2 VGNC VGNC:25506
Rattus norvegicus ABI2 RGD RGD:628771
Mus musculus ABI2 MGD MGI:106913