ALYREF - Aly/REF export factor Gene

Homo sapiens

Also known as ALY; BEF; REF; THOC4; ALY/REF

Gene ID: 10189 | Gene type: protein coding

About ALYREF

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,887,835-81,891,587 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 44.1), testis (RPKM 33.0) and 25 other tissues.

Summary

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]

ALYREF Products(1)

mRNA	Protein	Name
NM_005782.4	NP_005773.3	THO complex subunit 4

ALYREF Protein Structure

RRM_1

FoP_duplication

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

THO complex subunit 4

THO complex 4

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8	SCA8
Ataxia, Spinocerebellar, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00639	ALYREF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ALYREF	VGNC	VGNC:37823
Rattus norvegicus	ALYREF	RGD	RGD:1594679
Felis catus	ALYREF	VGNC	VGNC:59762
Macaca mulatta	ALYREF	VGNC	VGNC:69635
Bos taurus	ALYREF	VGNC	VGNC:25855
Mus musculus	ALYREF	MGD	MGI:1341044

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