GLRX3 - glutaredoxin 3 Gene

Homo sapiens

Also known as GRX3; GRX4; GLRX4; PICOT; TXNL2; TXNL3

Gene ID: 10539 | Gene type: protein coding

About GLRX3

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:130,136,391-130,180,377 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.3), lymph node (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit Apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for Cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

GLRX3 Products(3)

mRNA	Protein	Name
NM_001199868.2	NP_001186797.1	glutaredoxin-3 isoform 1
NM_001321980.2	NP_001308909.1	glutaredoxin-3 isoform 2
NM_006541.5	NP_006532.2	glutaredoxin-3 isoform 1

GLRX3 Protein Structure

Thioredoxin

Glutaredoxin

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

glutaredoxin-3

PKC-interacting cousin of thioredoxin

Related Diseases

Diseases

Alias

X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12	Mrx35
X-Linked Mental Retardation 12	X-Linked Mental Retardation 35

Transvestism

Dual-Role Transvestism	Fetishistic Transvestism
Cross Dresser	Transvestic Fetishism

Friedreich Ataxia

Friedreich Ataxia 1	FRDA
Friedreich Ataxia With Retained Reflexes	Frda1
Fa	Friedreich'S Ataxia
Hereditary Spinal Ataxia	Fa1
Friedreich'S Tabes	Hereditary Spinal Sclerosis
Spinocerebellar Ataxia, Friedreich	Friedreich Spinocerebellar Ataxia
Friedrich'S Ataxia

Transposition Of The Great Arteries, Dextro-Looped

Transposition Of The Great Arteries	DTGA1
Dextro-Looped Transposition Of The Great Arteries	DTGA
Congenitally Uncorrected Transposition Of The Great Arteries	Congenitally Uncorrected Transposition Of The Great Vessels
D-Tga	Isolated Ventriculoarterial Discordance
Ventriculoarterial Discordance With Atrioventricular Concordance	Dextro-Transposition Of The Great Arteries
Transposition Of The Great Vessels	Great Vessels Transposition
Transposition Of The Great Arteries, Dextro-Looped 1	Arteries, Great, Transposition, Dextro-Looped
Ventriculoarterial Discordance, Isolated	D-Transposition Of The Great Arteries
Complete Transposition	Tga
Tgv	Transposition Of Great Vessels
Transposition Of The Great Arteries Dextro-Looped 1	Dextro-Looped Transposition Of The Great Arteries 1
Discordant Ventriculoarterial Connection	Complete Transposition Of Great Vessels
Great Vessels Complete Transposition	Total Great Vessel Transposition
Transposition Of Great Arteries	Complete Tga - [Transposition Of The Great Arteries]
Tga - [Transposition Of Great Arteries]	Tgv - [Transposition Of Great Vessels]
Transposition Of Great Vessels Nos	Transposed Vessels Nos

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05498	GLRX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GLRX3	MGD	MGI:1353653
Macaca mulatta	GLRX3	VGNC	VGNC:103820
Rattus norvegicus	GLRX3	RGD	RGD:69414
Canis familiaris	GLRX3	VGNC	VGNC:41275
Bos taurus	GLRX3	VGNC	VGNC:29417

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