2. Gene
  3. CENPF - centromere protein F Gene

CENPF - centromere protein F Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CENF; hcp-1; CILD31; STROMS; PRO1779

Gene ID: 1063 | Gene type: protein coding

About CENPF

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:214,603,195-214,664,571 (from NCBI)

This gene has 5 transcripts (splice variants), 189 orthologues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues.

Summary

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with Cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

CENPF Products(1)

mRNA Protein Name
NM_016343.4 NP_057427.3 centromere protein F

CENPF Protein Structure

CENP-F_N

CENP-F_N: Cenp-F N-terminal domain (1 - 307)

CENP-F_leu_zip

CENP-F_leu_zip: Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 (1893 - 2035)

CENP-F_leu_zip

CENP-F_leu_zip: Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 (2131 - 2270)

CENP-F_leu_zip

CENP-F_leu_zip: Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 (2313 - 2452)

CENP-F_C_Rb_bdg

CENP-F_C_Rb_bdg: Rb-binding domain of kinetochore protein Cenp-F/LEK1 (2965 - 3013)

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  • 3114 a.a.
Protein Preferred Names Protein Names

centromere protein F

AH antigen

Related Diseases

Diseases Alias
Stromme Syndrome

Jejunal Atresia With Microcephaly And Ocular Anomalies

Apple Peel Syndrome With Microcephaly And Ocular Anomalies

STROMS

Cild31

Lethal Fetal Brain Malformation-Duodenal Atresia-Bilateral Renal Hypoplasia Syndrome

Ciliary Dyskinesia, Primary, 31, Formerly

Cild31, Formerly

Primary Ciliary Dyskinesia 31

Apple-Peel Intestinal Atresia-Ocular Anomalies-Microcephaly Syndrome

Jejunal Atresia-Microcephaly-Ocular Anomalies Syndrome

Ciliary Dyskinesia, Primary, 31

Dyskinesia, Ciliary, Primary, Type 31
Graft-Versus-Host Disease

Graft-Versus-Host Disease, Susceptibility To

Graft Versus Host Disease

GVHDS

Graft-Versus-Host Disease, Protection Against

Gvh

Graft-Vs-Host Disease

Gvhd - [Graft-Versus-Host Disease]

Graft-Versus-Host Reaction Or Disease

Gvh - [Graft-Versus-Host] Disease

Gvh - [Graft-Versus-Host] Reaction
Intestinal Atresia
Cystinuria

CSNU

Cystinuria Type B

Cystinuria Type A

Cystinuria, Type I, Formerly

Csnu1, Formerly

Cystinuria, Type Ii, Formerly

Cystinuria, Type Iii, Formerly

Csnu3, Formerly

Cystinuria, Type Non-I, Formerly

Cystinuria-Lysinuria

Cystinuria-Lysinuria Syndrome

Csnu1

Csnu3

Cystinuria 1

Cystinuria Type A/B

Cystinuria Type I

Cystinuria Type Ii

Cystinuria Type Iii

Cystinuria Type Non-I

Cystinuria, Type A/B

Cystinuria Type 1

Cystinuria - Lysinuria

Csnu - [Cystinuria]

Cystine Disease
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Mosaic Variegated Aneuploidy Syndrome 1

Mva Syndrome

MVA1

Mosaic Variegated Aneuploidy Syndrome, Type 1

Mosaic Variegated Aneuploidy Syndrome

Congenital Chromosomal Disease
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Familial Apolipoprotein C-Ii Deficiency

Familial Apoc-Ii Deficiency

Familial Apoc2 Deficiency

C-Ii Anapolipoproteinemia

Hyperlipoproteinemia, Type 1b

Hyperlipoproteinemia, Type Ib

Hyperlipoproteinemia Type I
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02479 CENPF Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CENPF VGNC VGNC:27176
Mus musculus CENPF MGD MGI:1313302
Felis catus CENPF VGNC VGNC:107851
Rattus norvegicus CENPF RGD RGD:628667
Macaca mulatta CENPF VGNC VGNC:71009