NPFFR2 - neuropeptide FF receptor 2 Gene

Homo sapiens

Also known as GPR74; NPFF2; NPGPR; HLWAR77

Gene ID: 10886 | Gene type: protein coding

About NPFFR2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:72,032,000-72,148,305 (from NCBI)

This gene has 5 transcripts (splice variants), 254 orthologues and 16 paralogues. Biased expression in placenta (RPKM 1.4), thyroid (RPKM 0.2) and 7 other tissues.

Summary

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

NPFFR2 Products(3)

mRNA	Protein	Name
NM_001144756.2	NP_001138228.1	neuropeptide FF receptor 2 isoform 3
NM_004885.3	NP_004876.3	neuropeptide FF receptor 2 isoform 1
NM_053036.3	NP_444264.1	neuropeptide FF receptor 2 isoform 1

NPFFR2 Protein Structure

7tm_1

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

neuropeptide FF receptor 2

G-protein coupled receptor 74

Related Diseases

Diseases

Alias

Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism

Nutmeg Liver

Chronic Passive Congestion Of Liver

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161405	NPFF1-R antagonist 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NPFFR2	VGNC	VGNC:43917
Macaca mulatta	NPFFR2	VGNC	VGNC:75295
Felis catus	NPFFR2	VGNC	VGNC:67441
Mus musculus	NPFFR2	MGD	MGI:1860130
Rattus norvegicus	NPFFR2	RGD	RGD:620168
Bos taurus	NPFFR2	VGNC	VGNC:32200