2. Gene
  3. DHRS4 - dehydrogenase/reductase 4 Gene

DHRS4 - dehydrogenase/reductase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL

Gene ID: 10901 | Gene type: protein coding

About DHRS4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,953,770-23,969,279 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 350 orthologues and 13 paralogues. Broad expression in kidney (RPKM 98.6), small intestine (RPKM 30.5) and 22 other tissues.

Summary

Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including cellular ketone metabolic process; positive regulation of Reactive Oxygen Species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

DHRS4 Products(7)

mRNA Protein Name
NM_001282987.2 NP_001269916.1 dehydrogenase/reductase SDR family member 4 isoform 2
NM_001282988.2 NP_001269917.1 dehydrogenase/reductase SDR family member 4 isoform 3
NM_001282989.2 NP_001269918.1 dehydrogenase/reductase SDR family member 4 isoform 4
NM_001282990.2 NP_001269919.1 dehydrogenase/reductase SDR family member 4 isoform 5
NM_001282991.2 NP_001269920.1 dehydrogenase/reductase SDR family member 4 isoform 6
NM_001411004.1 NP_001397933.1 dehydrogenase/reductase SDR family member 4 isoform 7
NM_021004.4 NP_066284.2 dehydrogenase/reductase SDR family member 4 isoform 1

DHRS4 Protein Structure

adh_short_C2

adh_short_C2: Enoyl-(Acyl carrier protein) reductase (41 - 273)

  • 0
  • 100
  • 200
  • 278 a.a.
Protein Preferred Names Protein Names

dehydrogenase/reductase SDR family member 4

NADPH-dependent carbonyl reductase

Related Diseases

Diseases Alias
Subjective Cognitive Decline
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03742 DHRS4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DHRS4 MGD MGI:90169
Rattus norvegicus DHRS4 RGD RGD:708482