2. Gene
  3. Raf1 - v-raf-leukemia viral oncogene 1 Gene

Raf1 - v-raf-leukemia viral oncogene 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cRaf; Craf1; Raf-1; c-Raf; v-Raf; 6430402F14Rik; D830050J10Rik

Gene ID: 110157 | Gene type: protein coding

About Raf1

Chromosome 6: 115,595,028-115,653,596 reverse strand.GRCm39:CM000999.3

This gene has 11 transcripts (splice variants), 219 orthologues, 23 paralogues and is associated with 101 phenotypes. Ubiquitous expression in CNS E14 (RPKM 5.6), whole brain E14.5 (RPKM 48.5) and 28 other tissues.

Summary

Enables small GTPase binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; gland development; and positive regulation of nitrogen compound metabolic process. Located in pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study Noonan syndrome 5. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Raf1 Products(3)

mRNA Protein Name
NM_001356334.2 NP_001343263.1 RAF proto-oncogene serine/threonine-protein kinase isoform 1
NM_029780.4 NP_084056.1 RAF proto-oncogene serine/threonine-protein kinase isoform 1
NM_001356333.2 NP_001343262.1 RAF proto-oncogene serine/threonine-protein kinase isoform 2

Raf1 Protein Structure

RBD_CRAF

RBD_CRAF: cd17135 (54 - 130)

C1_A_C-Raf

C1_A_C-Raf: cd20870 (135 - 186)

STKc_C-Raf

STKc_C-Raf: cd14149 (335 - 617)

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  • 648 a.a.
Protein Preferred Names Protein Names

RAF proto-oncogene serine/threonine-protein kinase

Craf1 transforming

murine sarcoma 3611 oncogene 1

proto-oncogene c-RAF

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib 99.92% Yes
HY-12057 Vemurafenib 99.83% Yes
HY-10331 Regorafenib 99.93% Yes
HY-10201A Sorafenib Tosylate 99.91% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-13308 Regorafenib Hydrochloride 99.58% Yes
HY-10331A Regorafenib monohydrate 99.96% Yes
HY-10331B Regorafenib mesylate / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-134813 MRTX1133 Inhibitor 99.42% Phase 2
HY-114491 Rineterkib Inhibitor 99.83% Phase 2
Pre-clinical Phase
Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-51424 PLX-4720 Inhibitor 99.91% Unkown
HY-11004 AZ 628 99.85% Unkown
HY-P1039A R18 TFA 98.48% Unkown
HY-W013411A Locostatin Inhibitor 99.82% Unkown
HY-123673 MCP110 Inhibitor 99.82% Unkown
HY-18832 AWL-II-38.3 97.47% Unkown
HY-122914 KRAS inhibitor-3 Inhibitor 99.65% Unkown
HY-15716 Kobe0065 98.01% Unkown
HY-I0678 Regorafénib N-oxyde (M2) 98.27% Unkown
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Unkown
HY-15717 Kobe2602 Inhibitor 99.55% Unkown
HY-158107 BBO-8520 Inhibitor / Unkown
HY-117737A RRD-251 99.94% Unkown
HY-136420 SJF-0628 Inhibitor 99.62% Unkown
HY-P1039 R18 / Unkown
HY-W013411 (E/Z)-Locostatin Inhibitor 99.52% Unkown
HY-10201S1 Sorafenib-d4 / Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-10331S1 Regorafenib-13C,d3 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-I0678S Regorafénib N-oxyde-d3 (M2) / Unkown
HY-I0678S1 Regorafénib N-oxyde (M2)-13C,d3 / Unkown
HY-RS11619 RAF1 Human Pre-designed siRNA Set A / Unkown
HY-RS11620 Raf1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11621 Raf1 Rat Pre-designed siRNA Set A / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Raf1 NCBI NCBI:5894