WWP2 - WW domain containing E3 ubiquitin protein ligase 2 Gene

Homo sapiens

Also known as AIP2; WWp2-like

Gene ID: 11060 | Gene type: protein coding

About WWP2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,762,332-69,941,739 (from NCBI)

This gene has 20 transcripts (splice variants), 132 orthologues and 24 paralogues. Ubiquitous expression in lung (RPKM 8.8), spleen (RPKM 8.4) and 25 other tissues.

Summary

This gene encodes a member of the Nedd4 family of E3 Ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

WWP2 Products(5)

mRNA	Protein	Name
NM_001270453.2	NP_001257382.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 4
NM_001270454.2	NP_001257383.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL
NM_001270455.2	NP_001257384.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-N
NM_007014.5	NP_008945.2	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-FL
NM_199424.3	NP_955456.1	NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform WWP2-C

WWP2 Protein Structure

HECT

0
200
400
600
800
870 a.a.

Protein Preferred Names

Protein Names

NEDD4-like E3 ubiquitin-protein ligase WWP2

HECT-type E3 ubiquitin transferase WWP2

Recombinant WWP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77507	WWP2 Protein, Human (sf9, His-GST)	O00308 (M1-E870)	≥95%

Related Diseases

Diseases

Alias

Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN	Spondyloepiphyseal Dysplasia Nishimura Type

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134417	NSC2805	Inhibitor	98.08%	Unkown
HY-RS15861	WWP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WWP2	VGNC	VGNC:67100
Rattus norvegicus	WWP2	RGD	RGD:1310091
Mus musculus	WWP2	MGD	MGI:1914144
Macaca mulatta	WWP2	VGNC	VGNC:103887
Canis familiaris	WWP2	VGNC	VGNC:48444
Bos taurus	WWP2	VGNC	VGNC:36979
Others	WWP2	NCBI

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