2. Gene
  3. MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HPK1

Gene ID: 11184 | Gene type: protein coding

About MAP4K1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,587,641-38,617,953 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 197 orthologues and 35 paralogues. Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MAP4K1 Products(3)

mRNA Protein Name
NM_007181.6 NP_009112.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 2
XM_011526404.2 XP_011524706.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform X1
NM_001042600.3 NP_001036065.1 mitogen-activated protein kinase kinase kinase kinase 1 isoform 1

MAP4K1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (17 - 273)

CNH

CNH: CNH domain (506 - 797)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

MAPK/ERK kinase kinase kinase 1

MEK kinase kinase 1

MEKKK 1

hematopoietic progenitor kinase 1

Related Diseases

Diseases Alias
Melnick-Needles Syndrome

MNS

Melnick-Needles Osteodysplasty

Osteodysplasty Of Melnick And Needles

Osteochondrodysplasias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138568 HPK1-IN-3 Inhibitor 99.32% Unkown
HY-138742 HPK1-IN-7 Inhibitor 99.33% Unkown
HY-148061 DB1113 99.28% Unkown
HY-143868 HPK1-IN-27 Inhibitor / Unkown
HY-143871 HPK1-IN-30 Inhibitor / Unkown
HY-156509 HPK1-IN-38 Inhibitor / Unkown
HY-RS08071 MAP4K1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08072 Map4k1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08073 Map4k1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAP4K1 MGD MGI:1346882
Bos taurus MAP4K1 VGNC VGNC:31204
Rattus norvegicus MAP4K1 RGD RGD:1305463
Felis catus MAP4K1 VGNC VGNC:97498
Canis familiaris MAP4K1 VGNC VGNC:42981
Others MAP4K1 NCBI