CELF3 - CUGBP Elav-like family member 3 Gene

Homo sapiens

Also known as CAGH4; ERDA4; ETR-1; TNRC4; BRUNOL1

Gene ID: 11189 | Gene type: protein coding

About CELF3

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,700,058-151,716,803 (from NCBI)

This gene has 7 transcripts (splice variants), 278 orthologues and 6 paralogues. Biased expression in brain (RPKM 11.4), adrenal (RPKM 3.2) and 4 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

CELF3 Products(5)

mRNA	Protein	Name
NM_001172648.4	NP_001166119.1	CUGBP Elav-like family member 3 isoform 2
NM_001172649.4	NP_001166120.1	CUGBP Elav-like family member 3 isoform 3
NM_001291106.2	NP_001278035.1	CUGBP Elav-like family member 3 isoform 4
NM_001291107.2	NP_001278036.1	CUGBP Elav-like family member 3 isoform 5
NM_007185.7	NP_009116.3	CUGBP Elav-like family member 3 isoform 1

CELF3 Protein Structure

RRM_1

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

CUGBP Elav-like family member 3

CAG repeat domain

Related Diseases

Diseases

Alias

Specific Language Impairment

Language Impairment, Specific

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Speech Disorder

Speech Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02461	CELF3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CELF3	VGNC	VGNC:60746
Canis familiaris	CELF3	VGNC	VGNC:39095
Bos taurus	CELF3	VGNC	VGNC:27168
Macaca mulatta	CELF3	VGNC	VGNC:70936
Mus musculus	CELF3	MGD	MGI:1926034
Rattus norvegicus	CELF3	RGD	RGD:1563168

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