NRM - nurim Gene

Homo sapiens

Also known as NRM29

Gene ID: 11270 | Gene type: protein coding

About NRM

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,688,049-30,691,420 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 182 orthologues. Ubiquitous expression in skin (RPKM 5.3), bone marrow (RPKM 5.1) and 25 other tissues.

Summary

The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

NRM Products(6)

mRNA	Protein	Name
NM_001270707.2	NP_001257636.1	nurim isoform 2
NM_001270708.2	NP_001257637.1	nurim isoform 3
NM_001270709.2	NP_001257638.1	nurim isoform 4
NM_001270710.2	NP_001257639.1	nurim isoform 5
NM_001384369.1	NP_001371298.1	nurim isoform 1
NM_007243.3	NP_009174.1	nurim isoform 1

NRM Protein Structure

NnrU

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

nurim

nuclear rim protein

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 20

Amyotrophic Lateral Sclerosis Type 20	ALS20
Sclerosis, Lateral, Amyotrophic, Type 20

Amyotrophic Lateral Sclerosis Type 5

Amyotrophic Lateral Sclerosis 5

Als5

Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 10	ALS10
Amyotrophic Lateral Sclerosis 10, With Or Without Ftd	Frontotemporal Lobar Degeneration, Tardbp-Related
Amyotrophic Lateral Sclerosis 10	Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia
Tardbp-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions	Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia And With Tdp43 Inclusions
Sclerosis, Lateral, Amyotrophic, Type Type 10

Acatalasemia

Acatalasia	Catalase Deficiency
Deficiency Of Catalase	ACATLAS
Takahara'S Disease	Takahara Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107654	Muscarine iodide	Agonist	≥97.0%	Unkown
HY-121404A	Muscarine chloride	Agonist	≥99.0%	Unkown
HY-121404	Muscarine	Agonist	/	Unkown
HY-RS09576	NRM Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NRM	VGNC	VGNC:49560
Rattus norvegicus	NRM	RGD	RGD:1302966
Macaca mulatta	NRM	VGNC	VGNC:75531
Felis catus	NRM	VGNC	VGNC:68568
Mus musculus	NRM	MGD	MGI:2146855
Others	NRM	NCBI

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