2. Gene
  3. KLF12 - KLF transcription factor 12 Gene

KLF12 - KLF transcription factor 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as AP2REP; AP-2rep; HSPC122

Gene ID: 11278 | Gene type: protein coding

About KLF12

Cytogenetic location: 13q22.1 Genomic coordinates (GRCh38): 13:73,686,089-74,306,045 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 22 paralogues. Ubiquitous expression in lymph node (RPKM 6.4), spleen (RPKM 4.4) and 24 other tissues.

Summary

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

KLF12 Products(12)

mRNA Protein Name
NM_001400136.1 NP_001387065.1 Krueppel-like factor 12 isoform 1
NM_001400139.1 NP_001387068.1 Krueppel-like factor 12 isoform 1
NM_001400141.1 NP_001387070.1 Krueppel-like factor 12 isoform 1
NM_001400146.1 NP_001387075.1 Krueppel-like factor 12 isoform 2
NM_001400147.1 NP_001387076.1 Krueppel-like factor 12 isoform 3
NM_001400148.1 NP_001387077.1 Krueppel-like factor 12 isoform 3
NM_001400149.1 NP_001387078.1 Krueppel-like factor 12 isoform 4
NM_001400150.1 NP_001387079.1 Krueppel-like factor 12 isoform 5
NM_001400151.1 NP_001387080.1 Krueppel-like factor 12 isoform 5
NM_001400152.1 NP_001387081.1 Krueppel-like factor 12 isoform 6
NM_001400153.1 NP_001387082.1 Krueppel-like factor 12 isoform 6
NM_007249.5 NP_009180.3 Krueppel-like factor 12 isoform 1

KLF12 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (333 - 350)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (364 - 388)

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  • 402 a.a.
Protein Preferred Names Protein Names

Krueppel-like factor 12

AP-2 repressor

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07333 KLF12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KLF12 VGNC VGNC:74028
Rattus norvegicus KLF12 RGD RGD:1309204
Felis catus KLF12 VGNC VGNC:102241
Canis familiaris KLF12 VGNC VGNC:42432
Mus musculus KLF12 MGD MGI:1333796
Bos taurus KLF12 VGNC VGNC:30628